There are two main distinct differences between a traditional 6 string Uke and a Guitalele. One is the tuning the other is the way it strung.
We will start with the 6 string uke. It employs the same standard uke tuning of GCEA. On the 6 string uke the nut is cut to allow a smaller unison string next to the C and another Next to the A. Thus tuned GCCEAA. The six string Uke can be played the exact same way as a stand uke but will have a fuller sound.
The Guitalele, like the Eddy Finn EF-G6 ,has 6 equally spaced strings like a guitar but is actually tuned ADGCEA which would be the same as a Guitar with a Capo placed on the 5th fret. The advantage in this tuning is that you can play it like a guitar, but because of the higher pitch, you can sound like a uke. You can also tune it like a standard guitar but at the lower pitch don’t expect that jangly Uke tone. Still, for guitar players wanting to transition to uke, this is a no brainer.